Stochastic modeling of the impact of random forcing on persistent hepatitis B virus infection
We developed a computational methodology for the analysis of the impact of random forcing on the patterns of virus persistence in HBV infection. We examine the issue of robustness vs. sensitivity in models of chronic infections (which relates to a fundamental question in immunology). The practical details of the implementation of the stochastic ODE models in the analysis of spontaneous recovery are presented. These include the effect of sampling of the parameter space, the number of simulation runs needed for a robust estimation of the mean and the variance of the spontaneous recovery pattern, the impact of the noise intensity and type on the response of the models. The stochastic models indicate that the relative frequency of spontaneous recovery from the persistent HBV infection is rather low, less than 10%, for the random forcing intensity varying within three orders of magnitude. The persistent infection with low viral load/CTL abundance is driven to recovery more frequently than the high viral load/CTL number type once the intensity of the random perturbations exceeds a certain level.
¿Cómo mantener su trabajo en los próximos oleadas de nuevas tecnologías?
Una gran cantidad de profesionales de la medicina están preocupados por sus puestos de trabajo si lo pierden en un futuro próximo debido a las próximas oleadas de nuevas tecnologías. Muchos de ellos piensan que serán reemplazados por robots y algoritmos. Mi teoría sobre el futuro se centra en el equilibrio entre el uso de las tecnologías de punta y manteniendo el toque humano. Significa que necesitamos para interactuar con la gente, a pesar de los robots y algoritmos podrían realizar mucho mejor que los seres humanos en muchas áreas. Pero ¿por qué no combinar las dos cosas?
gDocu
pubget:
http://pubget.com/paper/pgtmp_84031039169e97f4be8cd0f4d83d3db3/enfermedad-de-kawasaki-afeccion-cardiaca-durante-la-infancia
pubgle
JURN: http://www.redalyc.org/articulo.oa?id=81724108007
JANE
Ankle sprain injuries are the most common type of joint sprain. The prevalence of ankle joint sprains accounts for 21% of joint injuries in the body. Although somewhat rare, high-ankle or syndesmotic ankle sprains occur in up to 15% of ankle trauma. This article will present the pathomechanics of the high-ankle or syndesmotic sprain.
